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Cancer Research

The predominant lignan in flaxseeds is secoisolariciresinol diglucoside (SDG), making up around 95% of the seed’s lignan content. The remaining 5% consist of lariciresinol, pinoresinol, and matairesinol. After SDG lignan ingestion, bacteria in the colon act by converting the lignan into mammalian lignans, enterolactone, and enterodiol. These are structurally similar to estrogen, and have antioxidant activity and a weak estrogenic action. It also works as an antiestrogenic because its structure is very similar to the main form of estrogen, which allows its binding to the cell’s receptors, thus inhibiting the growth of cancer cells.


National Institutes of Health

Diabetes Health

"Daily lignan supplementation resulted in modest, yet statistically significant improvements in glycemic control in type 2 diabetic patients without apparently affecting fasting glucose, lipid profiles and insulin sensitivity. Further studies are needed to validate these findings and explore the efficacy of lignans on type 2 diabetes."


National Institutes of Heath

Prostate Health

Prostate cancer affects one-out-of-six men during their lifetime. Dietary factors are postulated to influence the development and progression of prostate cancer. Low-fat diets and flaxseed supplementation may offer potentially protective strategies.


National Institutes of Health

Heart Health

"Studies suggest that alpha-linolenic acid, which is found in flaxseed and flaxseed oil, might benefit people with heart disease. Early research also suggests that flaxseed might help lower high blood pressure, which plays a role in heart disease."


Mayo Clinic

Cholesterol

"Studies suggest that consuming whole or ground flaxseeds may lower cholesterol levels and blood pressure."


Harvard Medical School

Breast Health

"Breast tumors that contain estrogen receptors are called estrogen receptor positive (ER+) and tumors that lack estrogen receptors are estrogen receptor negative (ER−). Women who have ER+ tumors are more likely to respond to hormonal treatments than women with ER."


The Effect of Flaxseed in Breast Cancer: A Literature Review

Menopause Benefits

"Lignans are phytoestrogens that relieve the symptoms of menopause and can balance the effects of estrogen in the body by connecting to their receptors, as they have a very similar chemical structure as to an estrogen molecule."


National Institutes of Health

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